Publication Name	World Journal of Gastroenterology
Manuscript ID	107893
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	Leucine-rich repeat-containing protein 19 suppresses colorectal cancer by targeting cyclin-dependent kinase 6/E2F1 and remodeling immune microenvironment
Manuscript Source	Unsolicited Manuscript
All Author List	Si-Si Huang, Wei Chen, Deep K Vaishnani, Li-Juan Huang, Ji-Zhen Li, Shi-Rui Huang, Yan-Zhen Li and Qi-Peng Xie
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Zhejiang Province LY22H160005
Corresponding Author	Qi-Peng Xie, Deputy Director, MD, Department of Clinical Laboratory, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109 Xueyuan West Road, Wenzhou 325000, Zhejiang Province, China. xieqipeng@wmu.edu.cn
Key Words	Colorectal cancer; Tumor suppressor; Cell cycle arrest; Immune microenvironment; Chemotherapy sensitivity; Cyclin-dependent kinase 6/E2F1 axis; Oxaliplatin response; Leucine-rich repeat-containing protein 19; Immune infiltration; Precision medicine
Core Tip	Colorectal cancer (CRC) remains a major global health challenge due to tumor heterogeneity and treatment resistance. Leucine-rich repeat-containing protein 19 (LRRC19) is identified as a novel tumor suppressor in CRC, inhibiting the cyclin-dependent kinase 6/E2F1 axis to induce cell cycle arrest, remodeling the immune microenvironment by enhancing immune cell infiltration, and improving chemotherapy sensitivity to oxaliplatin. These findings provide new insights into the molecular mechanisms of CRC progression and suggest LRRC19 as a promising therapeutic target for precision medicine in CRC management.
Citation	Huang SS, Chen W, Vaishnani DK, Huang LJ, Li JZ, Huang SR, Li YZ, Xie QP. Leucine-rich repeat-containing protein 19 suppresses colorectal cancer by targeting cyclin-dependent kinase 6/E2F1 and remodeling immune microenvironment. World J Gastroenterol 2025; In press

Received	2025-03-31 13:43
Peer-Review Started	2025-03-31 13:43
To Make the First Decision
Return for Revision	2025-05-08 02:15
Revised	2025-05-20 19:11
Second Decision	2025-06-09 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-09 06:32
Articles in Press	2025-06-09 06:32
Publication Fee Transferred	2025-05-21 04:51
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com