Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	107966
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Survival benefit of primary tumor resection in pancreatic neuroendocrine tumors with unresectable liver metastases: A meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Jie Gong, Ben-Jian Gao and Ze-Hua Lei
Funding Agency and Grant Number
Corresponding Author	Ze-Hua Lei, MD, Professor, Department of Hepatopancreatobiliary Surgery, The People’s Hospital of Leshan, No. 238 Baita Street, Leshan 614000, Sichuan Province, China. leitsehua@126.com
Key Words	Primary tumor resection; Pancreatic neuroendocrine tumors; Liver metastases; Overall survival; Surveillance, Epidemiology, and End Results database
Core Tip	This study comprehensively evaluates the impact of primary tumor resection (PTR) on survival in patients with pancreatic neuroendocrine tumors and unresectable liver metastases. Our meta-analysis, involving 16 studies and 8761 patients, demonstrates that PTR significantly improves overall survival. Analysis of the Surveillance, Epidemiology, and End Results database further supports these findings, showing consistent survival benefits across different tumor differentiation levels. However, PTR’s effect on tumor grading remains unclear, highlighting the need for further large-scale prospective studies to refine surgical approaches for this patient population.
Citation	Gong J, Gao BJ, Lei ZH. Survival benefit of primary tumor resection in pancreatic neuroendocrine tumors with unresectable liver metastases: A meta-analysis. World J Gastrointest Surg 2025; In press

Received	2025-04-02 02:07
Peer-Review Started	2025-04-02 02:08
To Make the First Decision
Return for Revision	2025-04-16 09:46
Revised	2025-06-25 08:23
Second Decision	2025-07-31 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-31 07:00
Articles in Press	2025-07-31 07:00
Publication Fee Transferred	2025-06-30 07:46
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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