Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	107971
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	SAC3 domain containing 1 intervention in energy metabolism reprogramming assists in the progression of hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Xue-Jing Lin, Er-Jiang Tang, Bin Sun, Ai-Li Wang, Ying Chen, Lei Chen, Yi-Yang Xue, A-Jian Li and Chun-Ying Liu
Funding Agency and Grant Number	Funding Agency Grant Number Shanghai Yangpu District Science and Technology Commission No. YPQ202303 Shanghai Municipal Health Commission Clinical Research Special Project No. 2022410122 Shanghai Medical Innovation Research Special Project No. 22Y11908600
Corresponding Author	Chun-Ying Liu, Associate Professor, PhD, National Center for Liver Cancer, Naval Medical University, No. 366 Qianjv Road, Shanghai 201805, China. cyliu@sibcb.ac.cn
Key Words	SAC3 domain containing 1; Metabolic reprogramming; Glycolysis; Adenosine triphosphate production; β-Catenin/c-Myc axis; Hepatocellular carcinoma
Core Tip	The study revealed that the expression of SAC3 domain containing 1 (SAC3D1) was elevated in hepatocellular carcinoma and closely related to a poor prognosis. SAC3D1 facilitated the proliferation and migration of hepatocellular carcinoma cells in vitro and in vivo. The increase of SAC3D1 Leads to more β-Catenin accumulating in the nucleus, facilitating the expression of c-Myc, one of the upstream regulatory factors of glycolysis. The iCRT3, an antagonist of β-Catenin, could counteract the increase of c-Myc induced by SAC3D1, while also downregulating the expression of glycolysis-related proteins. In conclusion, SAC3D1 augmented glycolysis and adenosine triphosphate generation via β-Catenin/c-Myc axis.
Citation	Lin XJ, Tang JE, Sun B, Wang AL, Chen Y, Chen L, Xue YY, Li AJ, Liu CY. SAC3 domain containing 1 intervention in energy metabolism reprogramming assists in the progression of hepatocellular carcinoma. World J Gastrointest Oncol 2025; In press

Received	2025-04-11 08:17
Peer-Review Started	2025-04-11 08:17
To Make the First Decision
Return for Revision	2025-04-25 11:19
Revised	2025-05-08 08:54
Second Decision	2025-06-19 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-19 06:20
Articles in Press	2025-06-19 06:20
Publication Fee Transferred	2025-05-09 06:26
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Typeset the Manuscript

ISSN	1948-5204 (online)
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