Publication Name	World Journal of Meta-Analysis
Manuscript ID	107997
Country	India

Category	Biochemistry & Molecular Biology
Manuscript Type	Systematic Reviews
Article Title	Liquid biopsy in hepatobiliary and pancreatic cancers: A paradigm shift in early detection, prognostic stratification, and perioperative monitoring
Manuscript Source	Invited Manuscript
All Author List	Himanshu Agrawal, Binita Goswami, Nikhil Gupta and Nilanjana Singh
Funding Agency and Grant Number
Corresponding Author	Nikhil Gupta, FACS, FRCS (Gen Surg), Professor, Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, BKS Marg, Delhi 110001, India. nikhil_ms26@yahoo.co.in
Key Words	Perioperative monitoring; Pancreatic cancer; Hepatobiliary cancer; Circulating tumor DNA; Liquid biopsy
Core Tip	Liquid biopsy is a minimally invasive technique that detects circulating tumor DNA, circulating tumor cells, and other biomarkers in bodily fluids. It offers real-time monitoring of tumor dynamics, treatment response, and minimal residual disease. Unlike traditional tissue biopsies, liquid biopsy allows for repeated sampling, providing insights into tumor heterogeneity and evolution. It has applications in early cancer detection, prognosis, and guiding targeted therapies. Despite its advantages, challenges such as standardization, sensitivity, and specificity remain. Further research and technological advancements are needed to enhance its clinical utility.
Citation	Agrawal H, Goswami B, Gupta N, Singh N. Liquid biopsy in hepatobiliary and pancreatic cancers: A paradigm shift in early detection, prognostic stratification, and perioperative monitoring. World J Meta-Anal 2025; In press

Received	2025-04-02 08:24
Peer-Review Started	2025-04-02 09:04
To Make the First Decision
Return for Revision	2025-04-10 09:22
Revised	2025-04-10 10:47
Second Decision	2025-05-08 02:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-08 13:03
Articles in Press	2025-05-08 13:03
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ISSN	2308-3840 (online)
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