Publication Name	World Journal of Experimental Medicine
Manuscript ID	108034
Country	Egypt

Category	Medicine, Research & Experimental
Manuscript Type	Observational Study
Article Title	Circulating microRNAs and serum proteins in breast cancer patients: Diagnostic relevance and grade-specific expression patterns
Manuscript Source	Invited Manuscript
All Author List	Safinaz E El‑Toukhy, Heba K Nabih, Mahmoud M Kamel, Hossam Elmasry and Sherien M El-Daly
Funding Agency and Grant Number	Funding Agency Grant Number National Research Centre, Egypt No. E120504
Corresponding Author	Sherien M El-Daly, Professor, Department of Medical Biochemistry, Medical Research and Clinical Studies Institute, National Research Centre, 33 El Buhouth Street, Dokki, Giza 12622, Egypt. sm.el-daly@nrc.sci.eg
Key Words	Breast cancer; Liquid biopsy; Tumor grading; MicroRNAs; Cancer antigen 15-3; 8-hydroxy-2′-deoxyguanosine; Sensitivity; Specificity
Core Tip	This study highlights the diagnostic utility of a panel of circulating microRNAs (miRNAs), miR-21, miR-221, miR-1246, miR-145, and miR-382, in stratifying breast cancer patients by tumor grade. Notably, miR-21 and miR-1246 exhibited the highest diagnostic power in distinguishing patients from healthy controls. Importantly, integrating these miRNAs with traditional protein biomarkers cancer antigen 15-3 and 8-hydroxy-2′-deoxyguanosine significantly enhanced diagnostic accuracy and sensitivity, underscoring the value of a multi-marker approach for non-invasive breast cancer detection and grading.
Citation	El Toukhy SE, Nabih HK, Kamel MM, Elmasry H, El-Daly SM. Circulating microRNAs and serum proteins in breast cancer patients: Diagnostic relevance and grade-specific expression patterns. World J Exp Med 2025; In press

Received	2025-04-03 03:27
Peer-Review Started	2025-04-11 08:56
To Make the First Decision
Return for Revision	2025-05-01 02:45
Revised	2025-05-10 20:12
Second Decision	2025-06-20 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-20 07:40
Articles in Press	2025-06-20 07:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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