Publication Name	World Journal of Stem Cells
Manuscript ID	108049
Country	South Korea

Category	Dermatology
Manuscript Type	Basic Study
Article Title	Efficacy and safety of umbilical cord-derived mesenchymal stem cell-conditioned media for preventing and treating skin aging
Manuscript Source	Unsolicited Manuscript
All Author List	Hyunjun Ahn, Ho-Seong Han and Kye-Ho Lee
Funding Agency and Grant Number
Corresponding Author	Kye-Ho Lee, PhD, Stem Cell Treatment and Research Institute, Bio-Beauty & Health Company, No. 72 UN Village Gil, Yongsan-gu, Seoul 04420, South Korea. msoh@stc365.com
Key Words	Skin aging; Mesenchymal stem cell; Umbilical cord-derived mesenchymal stem cell; Mesenchymal stem cell-conditioned medium; Treating skin
Core Tip	Umbilical cord-derived mesenchymal stem cell-conditioned medium (UCMSC-CM) contains higher levels of effective factors than adipose-derived mesenchymal stem cell-conditioned medium, enhancing skin fibroblast proliferation and inhibiting melanin production in vitro. It promotes skin regeneration more effectively than adipose-derived mesenchymal stem cell-conditioned medium in aged skin in vivo. Subcutaneous injection of UCMSC-CM was the most effective method for promoting skin regeneration in aged skin in vivo. A non-clinical safety evaluation indicated that UCMSC-CM is a safe substance. These findings highlight UCMSC-CM as a promising and effective treatment for skin aging.
Citation	Ahn H, Han HS, Lee KH. Efficacy and safety of umbilical cord-derived mesenchymal stem cell-conditioned media for preventing and treating skin aging. World J Stem Cells 2025; In press

Received	2025-04-10 01:37
Peer-Review Started	2025-04-10 01:37
To Make the First Decision
Return for Revision	2025-05-13 12:25
Revised	2025-06-12 09:24
Second Decision	2025-08-22 09:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-29 10:42
Articles in Press	2025-08-29 10:42
Publication Fee Transferred	2025-06-19 10:05
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-09-06 15:05

ISSN	1948-0210 (online)
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