Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	108058
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Dynamics of tissue and fecal microbiota in active Crohn’s disease and their ability to predict disease state
Manuscript Source	Invited Manuscript
All Author List	Amit K Dutta, Dilip Abraham, Ira Praharaj, Blossom Benny, Karthikeyan Govindan, Zayina Zondervenni and AJ Joseph
Funding Agency and Grant Number	Funding Agency Grant Number Science and Engineering Research Board No. EMR/2016/007033
Corresponding Author	Amit K Dutta, Academic Fellow, Professor, Department of Gastroenterology, Christian Medical College, Ida Scudder Road, Vellore 632004, Tamil Nādu, India. akdutta1995@gmail.com
Key Words	Fecal microbiota; Mucosal microbiota; Crohn’s disease; Dysbiosis; Biomarker; Functional difference
Core Tip	Gut microbiota is emerging as a key player in the pathogenesis of Crohn’s disease (CD). The mucosal gut microbiota differs in structure and function compared to fecal microbiota, yet most studies have focused on fecal microbiota alone. We evaluated both mucosal and fecal microbiota in adults with active CD and compared this with the healthy controls. Our results show striking differences in bacterial structural and functional characteristics between mucosal and fecal samples in Crohn's disease. Additionally, the mucosal microbiota proved to be a good predictor of disease state and can serve as a novel potential biomarker for diagnosis of CD.
Citation	Dutta AK, Abraham D, Praharaj I, Benny B, Govindan K, Zondervenni Z, Joseph AJ. Dynamics of tissue and fecal microbiota in active Crohn’s disease and their ability to predict disease state. World J Gastrointest Pathophysiol 2025; In press

Received	2025-04-08 14:49
Peer-Review Started	2025-04-08 14:49
To Make the First Decision
Return for Revision	2025-04-16 15:06
Revised	2025-04-18 14:44
Second Decision	2025-06-11 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-11 09:26
Articles in Press	2025-06-11 09:26
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ISSN	2150-5330 (online)
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