Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	108068
Country	Egypt

Category	Pediatrics
Manuscript Type	Case Control Study
Article Title	Serum resistin levels in pediatric familial Mediterranean fever: Potential biomarker for inflammatory activity
Manuscript Source	Invited Manuscript
All Author List	Lamia M Morad, Eman Elsaadany, Shaima S Qassem, Maha S Elnady, Amira Ahmed Abdel-Kareem and Mohammed Al-Beltagi
Funding Agency and Grant Number
Corresponding Author	Mohammed Al-Beltagi, Department of Pediatrics, Faculty of Medicine, Tanta University, 1 Hassan Radwan Street, Tanta 31511, Algharbia, Egypt. mbelrem@hotmail.com
Key Words	Familial Mediterranean fever; Resistin; Inflammatory biomarkers; Acute phase response; Pediatric autoinflammatory disease; Serum inflammatory markers; Cytokine regulation
Core Tip	This study demonstrates that serum resistin levels are significantly elevated in patients with Familial Mediterranean Fever, particularly during acute attacks, and are closely associated with key inflammatory markers. Elevated resistin levels correlate with specific MEFV genotypes, such as E148Q and M694V, which are associated with more severe disease phenotypes. These findings suggest that resistin could be a valuable biomarker for diagnosing Familial Mediterranean Fever, monitoring disease activity, and assessing clinical severity. The study highlights the potential of resistin-targeted therapies and emphasizes the need for further research to explore their clinical applications in familial Mediterranean fever management.
Citation	Morad LM, Elsaadany E, Qassem SS, Elnady MS, Abdel-Kareem AA, Al-Beltagi M. Serum resistin levels in pediatric familial Mediterranean fever: Potential biomarker for inflammatory activity. World J Clin Pediatr 2025; In press

Received	2025-04-08 14:55
Peer-Review Started	2025-04-08 14:55
To Make the First Decision
Return for Revision	2025-05-20 08:24
Revised	2025-05-23 21:48
Second Decision	2025-08-07 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-08 09:49
Articles in Press	2025-08-08 09:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com