Publication Name	World Journal of Clinical Oncology
Manuscript ID	108071
Country	China

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	HOXC6-TIMELESS axis: Unveiling novel therapeutic strategies in bladder cancer
Manuscript Source	Invited Manuscript
All Author List	Meng-Meng Shi, Ming-Yue Guan, Shi Li, Jie-Yu Guo, Xing-Zhen Chen, Jing-Feng Tang and Ce-Fan Zhou
Funding Agency and Grant Number	Funding Agency Grant Number National Key R&D Program of China 2023YFC2507904 Hubei Strategic Science And Technology Talent Plan 2024DJA037 National Natural Science Foundation of China 32270768, 82273970 and 82370715 Innovation Group Project of Hubei Province 2023AFA026
Corresponding Author	Ce-Fan Zhou, PhD, Professor, School of Life and Health Sciences, Institute of Biomedical Research, National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, No. 28 Nanli Road, Wuhan 430068, Hubei Province, China. cefan@hbut.edu.cn
Key Words	Bladder cancer; HOXC6; Gene regulation; TIMELESS; Targeted therapy; Molecular oncology
Core Tip	The significant correlation between HOXC6 overexpression and bladder cancer (BLCA) progression has led to the establishment of a novel HOXC6-TIMELESS regulatory axis. In this letter, we aim to highlight the HOXC6-TIMELESS axis as a promising molecular target for the diagnosis and treatment of BLCA. Additionally, exploring therapeutic strategies such as RNA-based interventions, or circadian rhythm modulation may offer promising avenues to improve BLCA management and patient prognosis.
Citation	Shi MM, Guan MY, Li S, Guo JY, Chen XZ, Tang JF, Zhou CF. HOXC6-TIMELESS axis: Unveiling novel therapeutic strategies in bladder cancer. World J Clin Oncol 2025; In press

Received	2025-04-08 15:24
Peer-Review Started	2025-04-08 15:24
To Make the First Decision
Return for Revision	2025-04-23 11:49
Revised	2025-04-27 07:49
Second Decision	2025-06-11 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-11 09:32
Articles in Press	2025-06-11 09:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
Open Access	The significant correlation between HOXC6 overexpression and bladder cancer (BLCA) progression has led to the establishment of a novel HOXC6-TIMELESS regulatory axis. In this letter, we aim to highlight the HOXC6-TIMELESS axis as a promising molecular target for the diagnosis and treatment of BLCA. Additionally, exploring therapeutic strategies such as RNA-based interventions, or circadian rhythm modulation may offer promising avenues to improve BLCA management and patient prognosis.
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