Publication Name	World Journal of Hepatology
Manuscript ID	108096
Country	China

Category	Medicine, General & Internal
Manuscript Type	Observational Study
Article Title	Correlation between gynecomastia and endocrine regulation in patients with metabolic dysfunction-associated fatty liver disease: A cross-sectional study
Manuscript Source	Unsolicited Manuscript
All Author List	Ming-Huang Zhang, Ning Meng, Kang-Hui Zhang, Jun-Kang Yu, Chen-Hao Huang, Shu Yang and Ding-Yi Zhu
Funding Agency and Grant Number
Corresponding Author	Ning Meng, Chief Physician, PhD, Professor, Department of Thyroid and Breast Surgery, Affiliated Hospital of Hangzhou Normal University, No. 120 Jinhua Road, Gongchenqiao Street, Gongshu District, Hangzhou 310015, Zhejiang Province, China. mengning0894@126.com
Key Words	Metabolic dysfunction-associated fatty liver disease; Gynecomastia; Sex hormones; Metabolic syndrome; Receiver operating characteristic curve
Core Tip	This pioneering study investigated the unexplored link between the severity/duration of metabolic dysfunction-associated fatty liver disease (MASLD) and gynecomastia (GYN) in adult males, addressing acritical research gap. By integrating MASLD with body mass index and sex hormone imbalances, we revealed GYN as a novel marker for metabolic disorders (hyperglycemia, hypertension, dyslipidemia), shedding light on MASLD-driven endocrine disruption. Our findings underscore the necessity of holistic metabolic management—targeting obesity, MASLD, and hormonal imbalance—to mitigate GYN progression. This first-of-its-kind analysis provides a transformative clinical framework for early screening and intervention, positioning GYN as a sentinel for underlying metabolic dysfunction, thereby enhancing preventive strategies and therapeutic outcomes for MASLD-related comorbidities.
Citation	Zhang MH, Meng N, Zhang KH, Yu JK, Huang CH, Yang S, Zhu DY. Correlation between gynecomastia and endocrine regulation in patients with metabolic dysfunction-associated fatty liver disease: A cross-sectional study. World J Hepatol 2025; In press

Received	2025-04-07 09:23
Peer-Review Started	2025-04-08 00:07
To Make the First Decision
Return for Revision	2025-04-23 11:19
Revised	2025-05-06 05:23
Second Decision	2025-05-28 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-28 10:53
Articles in Press	2025-05-28 10:53
Publication Fee Transferred	2025-05-09 02:38
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Typeset the Manuscript

ISSN	1948-5182 (online)
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