Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	108127
Country	Malaysia

Category	Surgery
Manuscript Type	Randomized Controlled Trial
Article Title	Effects of preoperative immunonutrition vs standard oral nutrition in patients undergoing colorectal surgery: A randomized controlled trial
Manuscript Source	Invited Manuscript
All Author List	Manivaasan Pannirselvam, Zaidi Zakaria, Michael Pak-Kai Wong, Mohd Hady Shukri Abdul Satar, Nor Syarahani Jusoh, Andee Dzulkarnaen Zakaria and Muhammad Faeid Othman
Funding Agency and Grant Number	Funding Agency Grant Number Universiti Sains Malaysia, Short-Term Grant R501-LR-RND002-0000000342-0000
Corresponding Author	Muhammad Faeid Othman, MD, Department of Surgery, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Jalan Raja Perempuan Zainab II, Kubang Kerian 16150, Kelantan, Malaysia. faeid@usm.my
Key Words	Cancer surgery; Colorectal surgery; Gastrointestinal surgery; Immunonutrition; Postoperative complication
Core Tip	This randomized controlled trial evaluated the effects of preoperative immunonutrition vs standard oral nutrition supplements in patients undergoing colorectal surgery. Despite theoretical benefits, immunonutrition did not significantly improve postoperative gastrointestinal recovery, reduce infectious complications, or shorten hospital stay. All baseline and surgical variables were comparable between groups. The findings suggest that routine use of immunonutrition may not confer additional clinical advantages over standard supplementation in this patient population, challenging current recommendations and supporting a more individualized nutritional approach.
Citation	Pannirselvam M, Zakaria Z, Wong MPK, Abdul Satar MHS, Jusoh NS, Zakaria AD, Othman MF. Effects of preoperative immunonutrition vs standard oral nutrition in patients undergoing colorectal surgery: A randomized controlled trial. World J Gastrointest Surg 2025; In press

Received	2025-04-08 15:18
Peer-Review Started	2025-04-08 15:18
To Make the First Decision
Return for Revision	2025-05-14 11:02
Revised	2025-05-27 09:46
Second Decision	2025-07-31 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-31 06:22
Articles in Press	2025-07-31 06:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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