Publication Name	World Journal of Obstetrics and Gynecology
Manuscript ID	108149
Country	China

Category	Obstetrics & Gynecology
Manuscript Type	Minireviews
Article Title	Epigenetic clocks of female reproductive system aging: Current application and future prospects
Manuscript Source	Unsolicited Manuscript
All Author List	Jie Lin, Yang-Yi Chen, Shi-Jie Wang, Yang Zhang, Hai-Sheng Huang and Xiu-Quan Zhang
Funding Agency and Grant Number
Corresponding Author	Xiu-Quan Zhang, MD, PhD, Professor, Department of Obstetrics and Gynecology, Research Laboratory of Reproductive Genetics, Southern Medical University Shunde Hospital, No. 1 Jiazi Road, Lunjiao, Shunde District, Foshan 528308, Guangdong Province, China. xiuquan.zhang@hsc.utah.edu
Key Words	Endometrium; Epigenetic clock; Granulosa cell; Leukocyte; Methylation; Ovarian aging; Uterine aging
Core Tip	The aim of this minireview is to examine the application of epigenetic clocks in evaluating the functional status of the female reproductive system. Through the assessment of DNA methylation patterns, epigenetic clocks offer a means of estimating biological age and identifying age-related changes in reproductive tissues. Models derived from blood and reproductive-specific tissues demonstrate potential utility in assessing female reproductive health, particularly in quantifying and predicting the biological age of the reproductive system. Epigenetic clocks developed using endometrial tissue, follicular fluid, leukocytes, and granulosa cells exhibit varying capacities for predicting reproductive aging in females.
Citation	Lin J, Chen YY, Wang JS, Zhang Y, Huang HS, Zhang XQ. Epigenetic clocks of female reproductive system aging: Current application and future prospects. World J Obstet Gynecol 2025; In press

Received	2025-04-07 09:58
Peer-Review Started	2025-04-07 09:58
To Make the First Decision
Return for Revision	2025-04-16 10:50
Revised	2025-04-29 14:09
Second Decision	2025-06-13 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-13 08:26
Articles in Press	2025-06-13 08:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-6220 (online)
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