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Publication Name World Journal of Gastrointestinal Surgery
Manuscript ID 108160
Country China
Category Gastroenterology & Hepatology
Manuscript Type Letter to the Editor
Article Title Adjuvant chemotherapy for gallbladder cancer: Current evidence, controversies, and future directions
Manuscript Source Unsolicited Manuscript
All Author List Jin-Wei Dai, Yi-Xuan Xing and Nian-Zhe Sun
Funding Agency and Grant Number
Corresponding Author Nian-Zhe Sun, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha 410008, Hunan Province, China. sunnzh201921@sina.com
Key Words Gallbladder cancer; Adjuvant chemotherapy; National Cancer Database; Retrospective analysis; Cancer staging
Core Tip Whether patients with stage II gallbladder cancer should routinely receive adjuvant chemotherapy after surgery remains uncertain. The analysis by Kim et al, based on National Cancer Database data, found no statistically significant survival benefit associated with chemotherapy in these patients. However, the results should not be hastily interpreted as evidence against chemotherapy altogether. Instead, clinicians must consider individualized treatment decisions based on pathological features and the patient’s overall health condition. This article further evaluated the strengths and weaknesses of Kim et al’s research design. It recommended conducting future studies, ideally prospective clinical trials or refined retrospective analyses, to better clarify chemotherapy’s role in this context.
Citation Dai JW, Xing YX, Sun NZ. Adjuvant chemotherapy for gallbladder cancer: Current evidence, controversies, and future directions. World J Gastrointest Surg 2025; In press
Received
2025-04-07 04:35
Peer-Review Started
2025-04-07 04:35
To Make the First Decision
Return for Revision
2025-04-17 10:41
Revised
2025-04-24 13:57
Second Decision
2025-06-20 02:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-06-20 06:50
Articles in Press
2025-06-20 06:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-9366 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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