Publication Name	World Journal of Clinical Oncology
Manuscript ID	108173
Country	China

Category	Nursing
Manuscript Type	Retrospective Study
Article Title	Compound lidocaine cream with warm compress for pain relief in ultrasound-guided peripherally inserted central catheter placement for cancer patients
Manuscript Source	Invited Manuscript
All Author List	Yan Wang, Xue-Ni Yang, Sheng Ji, Yu-Mei Zhang, Yi Wang, Yan-Mei Wang and Yue-Xia Gu
Funding Agency and Grant Number	Funding Agency Grant Number Discipline Promotion Program of Shanghai Fourth People’s Hospital No. SY-XKZT-2021-2006
Corresponding Author	Yue-Xia Gu, Chief Nurse, Department of Nursing, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, No. 1279 Sanmen Road, Hongkou District, Shanghai 200434, China. shdsyy_guyuexia@163.com
Key Words	Ultrasound-guided; Peripherally inserted central catheter placement; Pain relief; Compound lidocaine cream; Warm compress; Retrospective study; Cancer patients
Core Tip	his study presents a non-invasive analgesic protocol that combines compound lidocaine cream (2.5% lidocaine + 2.5% prilocaine) with a 40-45 °C thermal compress to mitigate pain during ultrasound-guided peripherally inserted central catheter placement in cancer patients. By leveraging thermos responsive mechanisms to enhance transdermal drug penetration, this method achieves dermal anesthesia within 8-10 minutes, effectively reducing initial puncture pain and minimizing the risk of vasospasm associated with traditional lidocaine infiltration. A retrospective analysis of 88 patients revealed significantly lower pain scores and a high level of patient satisfaction (97.7%), while maintaining procedural success rates comparable to conventional methods. Mechanistically, the thermal activation of transient receptor potential vanilloid 1 channel may facilitate deeper drug diffusion, providing rapid analgesia for urgent oncology interventions.
Citation	Wang Y, Yang XN, Ji S, Zhang YM, Wang Y, Wang YM, Gu YX. Compound lidocaine cream with warm compress for pain relief in ultrasound-guided peripherally inserted central catheter placement for cancer patients. World J Clin Oncol 2025; In press

Received	2025-04-09 01:58
Peer-Review Started	2025-04-09 01:58
To Make the First Decision
Return for Revision	2025-04-14 10:44
Revised	2025-04-22 14:16
Second Decision	2025-06-04 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-04 10:03
Articles in Press	2025-06-04 10:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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