Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	108205
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Effects of radiotherapy on lymphocytes in patients with middle and lower esophageal cancer and its relationship with prognosis
Manuscript Source	Unsolicited Manuscript
All Author List	Shu-Guang Li, Yang Liu, Xue-Yuan Zhang, You-Mei Li, Wen-Bin Shen and Shu-Chai Zhu
Funding Agency and Grant Number
Corresponding Author	Shu-Chai Zhu, Chief Physician, Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, No. 12 Jiankang Road, Shijiazhuang 050011, Hebei Province, China. hbmuzhusc1965@hebmu.edu.cn
Key Words	Esophageal tumor; Radiotherapy; Radiation-induced lymphopenia; Prognosis; Organs at risk volume; Immunosuppression
Core Tip	Definitive chemoradiotherapy is the standard treatment for locally advanced esophageal cancer. However, radiotherapy (RT) often affects the immune system of patients. One of the possible mechanisms of lymphopenia after RT is that a large number of circulating lymphocytes in the systemic and pulmonary circulation will be killed by more sessions of low-dose radiation. This study showed that there was a relationship between radiation-induced lymphopenia (RIL) and the prognosis of esophageal squamous cell carcinoma patients, and identified several possible mechanisms of RT parameters in regulating the lymphocyte count during RT. The combination of tumor clinical stage and RT parameters has a certain predictive value for RIL and patient prognosis.
Citation	Li SG, Liu Y, Zhang XY, Li YM, Shen WB, Zhu SC. Effects of radiotherapy on lymphocytes in patients with middle and lower esophageal cancer and its relationship with prognosis. World J Gastrointest Oncol 2025; In press

Received	2025-04-15 09:37
Peer-Review Started	2025-04-15 09:37
To Make the First Decision
Return for Revision	2025-04-30 07:17
Revised	2025-05-12 07:42
Second Decision	2025-05-29 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-05-29 06:38
Articles in Press	2025-05-29 06:38
Publication Fee Transferred	2025-05-17 01:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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