Publication Name	World Journal of Clinical Oncology
Manuscript ID	108220
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Obesity as a risk factor for early-onset colorectal cancer: Evidence from a nationally representative database
Manuscript Source	Unsolicited Manuscript
All Author List	Omar Khattab, Mohamed Alharami, Frhaan Zahrawi and Ammar Hemaidan
Funding Agency and Grant Number
Corresponding Author	Omar Khattab, MD, Department of Internal Medicine, Kettering Health Network, 3535 Southern Boulevard, Kettering, OH 45429, United States. omar.khattab@ketteringhealth.org
Key Words	Early-onset colorectal cancer; Obesity; Body roundness index; Body mass index; Waist circumference; Risk factors; Logistic regression; Propensity score matching
Core Tip	Early-onset colorectal cancer (CRC) is rising globally, yet its modifiable risk factors remain unclear. This cross-sectional study analyzed over 30000 United States adults aged 18-49 using the National Health and Nutrition Examination Survey data (1999-2023) to assess the relationship between obesity and early-onset CRC (eoCRC). Among multiple obesity indices, body roundness index (BRI) emerged as the strongest predictor of eoCRC risk—even after adjusting for body mass index, waist circumference, and lifestyle factors. BRI offers a more holistic assessment of body fat distribution, making it a potentially superior screening tool for young adults at higher risk for CRC.
Citation	Khattab O, Alharami M, Zahrawi F, Hemaidan A. Obesity as a risk factor for early-onset colorectal cancer: Evidence from a nationally representative database. World J Clin Oncol 2025; In press

Received	2025-04-17 06:24
Peer-Review Started	2025-04-17 06:24
To Make the First Decision
Return for Revision	2025-04-26 19:10
Revised	2025-05-08 04:29
Second Decision	2025-06-06 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-07 05:27
Articles in Press	2025-06-07 05:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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