Publication Name	World Journal of Hepatology
Manuscript ID	108253
Country	United Arab Emirates

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	New hope in treating progressive familial intrahepatic cholestasis in children
Manuscript Source	Invited Manuscript
All Author List	Lama Ebrahim Mkarem, Mohammed Ali Hosny Batika and Rana R Bitar
Funding Agency and Grant Number
Corresponding Author	Rana R Bitar, Assistant Professor, Division of Pediatric Gastroenterology, Sheikh Khalifa Medical City, Al Karamah St., Abu Dhabi 51900, United Arab Emirates. rahmad@seha.ae
Key Words	Progressive familial intrahepatic cholestasis; Odevixibat; Intestinal bile acid transporter inhibitor; Maralixibat
Core Tip	Progressive familial intrahepatic cholestasis is a heterogenous autosomal recessive progressive cholestatic liver disease with varying genotype and phenotype. Identifying the underlying genetic disorder allows better understanding of the clinical phenotype and associated complications. Management is aimed at nutritional support, trying to make bile more hydrophilic by administering ursodeoxycholic acid and control of pruritus. Surgical biliary diversion has proved to reduce bile acid levels and improve pruritis in some patients. New hope exists with ileal bile acid transporter receptor inhibitors, however more data is still required. The ultimate treatment for end stage liver disease and persistent pruritus is liver transplantation.
Citation	Mkarem LE, Batika MAH, Bitar RR. New hope in treating progressive familial intrahepatic cholestasis in children. World J Hepatol 2025; In press

Received	2025-04-09 02:03
Peer-Review Started	2025-04-09 02:03
To Make the First Decision
Return for Revision	2025-04-25 13:02
Revised	2025-04-25 20:59
Second Decision	2025-06-23 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-23 07:36
Articles in Press	2025-06-23 07:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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