Publication Name	World Journal of Gastroenterology
Manuscript ID	108271
Country	Mexico

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Phospholipase D2: A biomarker implicated in various pancreatic diseases beyond acute pancreatitis
Manuscript Source	Invited Manuscript
All Author List	Ana I Tornel Avelar, Christian Navarro Gerrard and Bryan Adrian Priego Parra
Funding Agency and Grant Number	Funding Agency Grant Number Mexican Association of Gastroenterology 2023 for the scholarship warded
Corresponding Author	Bryan Adrian Priego Parra, MD, PhD, Department of Digestive Physiology and Gastrointestinal Motility, Institute of Medical-Biological Research, Universidad Veracruzana, Iturbide S/N Entre Carmen Serdán y 20 de Noviembre, Col. Flores Magón, Veracruz 91700, Veracruz, Mexico. bryanpriegop@gmail.com
Key Words	Phospholipase D2; Acute pancreatitis; Chronic pancreatitis; Pancreatic Biomarkers; Pancreatic cancer; Sexual dimorphism
Core Tip	Phospholipase D2 is a key enzyme involved in the hydrolysis of phospholipids. It has been implicated in processes, such as neutrophil migration, the inflammatory response, apoptosis, cell migration, and adhesion in various pathologies. This letter to the editor analyzes multiple research sources on phospholipase D2 in pancreatic conditions, including acute pancreatitis, chronic pancreatitis, and pancreatic cancer. It also highlights the need for future research to consider sex differences in the expression of this enzyme and to evaluate its applicability in clinical practice.
Citation	Tornel Avelar AI, Gerrard CN, Priego Parra BA. Phospholipase D2: A biomarker implicated in various pancreatic diseases beyond acute pancreatitis. World J Gastroenterol 2025; In press

Received	2025-04-09 10:11
Peer-Review Started	2025-04-09 10:12
To Make the First Decision
Return for Revision	2025-05-10 19:00
Revised	2025-05-24 02:32
Second Decision	2025-07-04 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-04 07:21
Articles in Press	2025-07-04 07:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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