Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	108277
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Correlation between perineural invasion and clinicopathological characteristics in pancreatic cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Liang Lu, Chuang Ge, Ruo-Chen Wang and Hong Zang
Funding Agency and Grant Number
Corresponding Author	Hong Zang, MD, PhD, Department of Hepatobiliary Surgery, Nantong First People’s Hospital, No. 666 Shengli Road, Nantong 226001, Jiangsu Province, China. 13862901007@163.com
Key Words	Perineural invasion; Pancreatic cancer; Clinicopathological characteristics; Predictive model; Risk factors
Core Tip	This study investigates the association between perineural invasion (PNI) and clinicopathological features in pancreatic cancer (PC). A total of 112 PC cases were analyzed and categorized into PNI and non-PNI groups. Tumor location, size, carbohydrate antigen 19-9 levels, abdominal pain, differentiation, and lymph node invasion were identified as independent risk factors for PNI. A predictive model based on these variables demonstrated high accuracy and consistency. These findings offer valuable insight into the pathological mechanisms of PNI and may aid in early diagnosis and individualized treatment strategies for PC patients.
Citation	Lu XL, Ge C, Wang RC, Zang H. Correlation between perineural invasion and clinicopathological characteristics in pancreatic cancer. World J Gastrointest Oncol 2025; In press

Received	2025-04-10 01:32
Peer-Review Started	2025-04-10 01:32
To Make the First Decision
Return for Revision	2025-05-22 10:07
Revised	2025-06-04 06:40
Second Decision	2025-07-18 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-18 07:51
Articles in Press	2025-07-18 07:51
Publication Fee Transferred	2025-06-10 06:11
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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