Publication Name	World Journal of Gastroenterology
Manuscript ID	108321
Country	China

Category	Medical Laboratory Technology
Manuscript Type	Observational Study
Article Title	Construction of a community-based primary screening and hospital-based confirmatory screening pathway in pediatric nonalcoholic fatty liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Ming-Jie Yao, Yun-Fei Xing, Shu-Hong Liu, Ya-Fei Peng, Shu-Han Yang, Juan-Juan Chen, Jing-Min Zhao and Hui Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82272433 Fujian Provincial Key Laboratory of Hepatic Drug Research 2022-YF-0050 Major Science and Technology Projects for Health of Zhejiang Province WKJ-ZJ-2216 Cyrus Tang Foundation for Young Scholar 2022 (2022-B126)
Corresponding Author	Hui Wang, Assistant Professor, PhD, Department of Maternal and Child Health, Peking University Health Science Center, No. 38 Xueyuan Road, Haidian District, Beijing 100191, China. huiwang@bjmu.edu.cn
Key Words	Children; Nonalcoholic fatty liver disease; Significant fibrosis; Machine learning; Less invasive test
Core Tip	Fibrosis is a critical event in the progression of pediatric nonalcoholic fatty liver disease (NAFLD), and practical and efficient screening indices for early detection and referral in a large population are urgently needed. Different indices were generated for tertiary hospitals and community health centers based on the data of Chinese NAFLD children individually confirmed via liver biopsy. Serial tests were able to dramatically increase the positive predictive value. The sequential implementation of these less invasive screening predictors and referral systems could help physicians in accurately detecting the risk population accurately; however, broad age/ethnic range population validation is needed.
Citation	Yao MJ, Xing YF, Liu SH, Peng YF, Yang SH, Chen JJ, Zhao JM, Wang H. Construction of a community-based primary screening and hospital-based confirmatory screening pathway in pediatric nonalcoholic fatty liver disease. World J Gastroenterol 2025; In press

Received	2025-04-18 02:44
Peer-Review Started	2025-04-18 02:44
To Make the First Decision
Return for Revision	2025-04-29 02:29
Revised	2025-05-12 12:52
Second Decision	2025-07-02 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-02 06:01
Articles in Press	2025-07-02 06:01
Publication Fee Transferred	2025-05-17 05:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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