Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	108329
Country	Russia

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Case Report
Article Title	Arrhythmogenic cardiomyopathy in children, on the link between injurious mutations and inflammation: Two case reports and review of the literature
Manuscript Source	Invited Manuscript
All Author List	Ekaterina Nikitina, Olga Kofeynikova, Anna Zlotina, Tatiana Pervunina, Elena Vasichkina, Alexey Golovkin, Olga Kalinina and Anna Kostareva
Funding Agency and Grant Number	Funding Agency Grant Number Russian Science Foundation No. 24-15-20026/12.04.2024 St. Petersburg Research Foundation No. 24-15-20026/24.05.2024
Corresponding Author	Anna Kostareva, Director, MD, Professor, Institute of Molecular Biology and Genetics, Almazov National Medical Research Centre, Akkuratova str., 2, Saint-Petersburg 197341, Russia. anna.kostareva@ki.se
Key Words	Arrhythmogenic cardiomyopathy; Hot phase; Aseptic inflammation; Desmosomal mutations; Cytoskeletal derangements; Case report
Core Tip	Arrhythmogenic cardiomyopathy (ACM) is characterized by intercalated disc remodeling and cardiomyocytes death, which can lead to fibro-fatty replacement and severe heart failure. In some children, ACM presents with a “hot phase” and may be mistaken for acute myocarditis or coronary artery pathology. In this report, we describe two cases of the “hot phase” presentation and discuss the molecular mechanisms of this phenomenon.
Citation	Nikitina E, Kofeynikova O, Zlotina A, Pervunina T, Vasichkina E, Golovkin A, Kalinina O, Kostareva A. Arrhythmogenic cardiomyopathy in children, on the link between injurious mutations and inflammation: Two case reports and review of the literature. World J Clin Pediatr 2025; In press

Received	2025-04-11 09:22
Peer-Review Started	2025-04-11 09:22
To Make the First Decision
Return for Revision	2025-04-22 03:04
Revised	2025-05-05 16:28
Second Decision	2025-07-14 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-15 06:33
Articles in Press	2025-07-15 06:33
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ISSN	2219-2808 (online)
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