Publication Name	World Journal of Diabetes
Manuscript ID	108344
Country	South Korea

Category	Health Care Sciences & Services
Manuscript Type	Retrospective Cohort Study
Article Title	Exercise intensity and the risk of end-stage renal disease in diabetes: A nationwide population-based study
Manuscript Source	Unsolicited Manuscript
All Author List	Eun Hui Bae, Sang Yup Lim, Bong-Seong Kim, Kyung-Do Han, Sang Heon Suh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma and Soo Wan Kim
Funding Agency and Grant Number	Funding Agency Grant Number the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) RS-2023-00217317 Chonnam National University Grant 2024-0444-01 the Chonnam National University Hospital Institute for Biomedical Science BCRI24032
Corresponding Author	Soo Wan Kim, MD, PhD, Professor, Department of Internal Medicine, Chonnam National University Medical School, Jebongro 42, Gwangju 61469, South Korea. skimw@chonnam.ac.kr
Key Words	Exercise; Diabetes mellitus; End-stage renal disease; Chronic kidney disease; Intensity; Duration
Core Tip	This large-scale nationwide cohort study explored the association between exercise intensity and the risk of end-stage renal disease (ESRD) in patients with diabetes. The findings indicate that high-intensity physical activity (≥ 1500 metabolic equivalents of task-min/week) significantly reduced ESRD risk, particularly in those with diabetes for over 10 years. Subgroup analyses revealed the greatest benefit in patients without hypertension, non-smokers, and those with higher body mass index. These findings highlight the potential of targeted exercise interventions to delay renal complications in diabetes management.
Citation	Bae EH, Lim SY, Kim B, Han KD, Suh SH, Choi HS, Kim CS, Ma SK, Kim SW. Exercise intensity and the risk of end-stage renal disease in diabetes: A nationwide population-based study. World J Diabetes 2025; In press

Received	2025-04-13 11:40
Peer-Review Started	2025-04-16 07:38
To Make the First Decision
Return for Revision	2025-05-07 03:49
Revised	2025-05-19 07:20
Second Decision	2025-06-16 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-23 09:37
Articles in Press	2025-06-23 09:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
Open Access	This large-scale nationwide cohort study explored the association between exercise intensity and the risk of end-stage renal disease (ESRD) in patients with diabetes. The findings indicate that high-intensity physical activity (≥ 1500 metabolic equivalents of task-min/week) significantly reduced ESRD risk, particularly in those with diabetes for over 10 years. Subgroup analyses revealed the greatest benefit in patients without hypertension, non-smokers, and those with higher body mass index. These findings highlight the potential of targeted exercise interventions to delay renal complications in diabetes management.
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