Publication Name	World Journal of Clinical Oncology
Manuscript ID	108371
Country	China

Category	Oncology
Manuscript Type	Case Report
Article Title	Exploration of preventive treatment for high risk patients with metachronous multiple esophageal squamous cell carcinoma: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Dan Chen, Ding-Fu Zhong and Dong Liu
Funding Agency and Grant Number	Funding Agency Grant Number The Role of Amyloid Precursor Protein in Facilitating the Progression of NASH-Associated Hepatocarcinoma 2022-4-145
Corresponding Author	Dong Liu, Associate Chief Physician, Department of Hepatobiliary and Pancreatic Gastroenterology, Affiliated Jinhua Hospital of Wenzhou Medical University, Jinhua People’s Hospital, No.267 Danxi East Road, Jindong District, Jinhua 321000, Zhejiang Province, China. li375dong@163.com
Key Words	Multiple dysplastic lesions; Metachronous multiple esophageal squamous cell carcinomas; Lugol-voiding lesions; Lugol chromoendoscopy; Radiotherapy; Case report
Core Tip	The grade of Lugol-voiding lesions is associated with risk of metachronous squamous cell carcinomas (SCCs). Effective methods to prevent metachronous multiple SCCs are needed in survivors of esophageal squamous cell carcinomas. We present the first case of multiple dysplastic lesions of esophagus cured by radiotherapy. This case indicated that radiotherapy after endoscopic submucosal dissection might be a safe and effective optional therapeutic strategy to prevent metachronous multiple esophageal SCCs.
Citation	Chen D, Zhong DF, Liu D. Exploration of preventive treatment for high risk patients with metachronous multiple esophageal squamous cell carcinoma: A case report. World J Clin Oncol 2025; In press

Received	2025-04-23 04:03
Peer-Review Started	2025-04-23 04:03
To Make the First Decision
Return for Revision	2025-05-17 07:34
Revised	2025-06-14 16:42
Second Decision	2025-07-17 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-17 08:48
Articles in Press	2025-07-17 08:48
Publication Fee Transferred	2025-06-17 13:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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