Publication Name	World Journal of Gastroenterology
Manuscript ID	108375
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Ulcerative colitis: Timeline to a cure
Manuscript Source	Invited Manuscript
All Author List	Jay Pravda
Funding Agency and Grant Number
Corresponding Author	Jay Pravda, Department of Disease Pathogenesis, Inflammatory Disease Research Centre, 4371 Northlake Blvd No. 247, Palm Beach Gardens, FL 33410, United States. jay.pravda@protonmail.com
Key Words	Ulcerative colitis; Pathogenesis; Treatment; Hydrogen peroxide; Common pathway
Core Tip	Since the mid-20th century, research into the causes of ulcerative colitis has predominantly focused on the immune system and microbiome, overlooking the colonic epithelium’s role in its pathogenesis. This conformation bias has delayed recognition of the causal role played by colonocyte hydrogen peroxide in the pathogenesis of this inflammatory bowel disease. Notably, fewer than a dozen studies since that time have laid the groundwork for this conclusion. This review critically examines these foundational studies through the lens of contemporary biomedical science, tracing their evolution toward the identification of a causal role for colonocyte hydrogen peroxide in the pathogenesis of ulcerative colitis.
Citation	Pravda J. Ulcerative colitis: Timeline to a cure. World J Gastroenterol 2025; In press

Received	2025-04-12 08:57
Peer-Review Started	2025-04-12 08:57
To Make the First Decision
Return for Revision	2025-04-23 01:27
Revised	2025-05-01 17:00
Second Decision	2025-06-27 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-27 06:40
Articles in Press	2025-06-27 06:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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