Publication Name	World Journal of Orthopedics
Manuscript ID	108407
Country	China

Category	Orthopedics
Manuscript Type	Review
Article Title	Skeletal stem cells, a new direction for the treatment of bone and joint diseases
Manuscript Source	Invited Manuscript
All Author List	Can Liu, Jie Jian, Yang-Fei Yi, Yi-Tong Ding, Yao Chen, Zhong-Wen Tang, Jie Wen and Yu-Fei Li
Funding Agency and Grant Number	Funding Agency Grant Number Science project of Hunan Provincial Healthy Commission 20230844
Corresponding Author	Jie Wen, Associate Professor, Department of Pediatric Orthopedics, Hunan Normal University School of Medicine, No.61 West Jiefang Rd, Changsha 410005, Hunan Province, China. cashwj@qq.com
Key Words	Skeletal stem cells; Epiphyseal injuries; Osteoarthritis; Avascular necrosis of the femoral head; Cartilage injury
Core Tip	Skeletal stem cells (SSCs) are tissue-specific stem cells characterized by their capacity for self-renewal and their position at the apex of the differentiation hierarchy. They can generate mature bone cell types essential for bone development, maintenance, and repair. Lineage tracing experiments have demonstrated that SSCs reside in the bone marrow, periosteum, and the resting zone of the growth plate. These findings not only enhance our understanding of bone growth and development mechanisms but also offer novel therapeutic strategies for conditions such as epiphyseal injuries, fractures, osteoarthritis (OA), and other orthopedic diseases. Recent advancements in biological scaffold technology, combined with 3D printing techniques, have facilitated bone tissue regeneration using bone stem cells. Additionally, bone stem cells have shown promise in cartilage regeneration therapy, particularly in treating degenerative diseases like OA and articular cartilage damage, thereby improving joint function. This review summarizes the latest research progress on the role of SSC in bone and joint injury regeneration and provides new insights into potential therapeutic approaches.
Citation	Liu C, Jian J, Yi YF, Ding YT, Chen Y, Tang ZW, Wen J, Li YF. Skeletal stem cells, a new direction for the treatment of bone and joint diseases. World J Orthop 2025; In press

Received	2025-04-14 04:06
Peer-Review Started	2025-04-14 04:06
To Make the First Decision
Return for Revision	2025-04-18 14:14
Revised	2025-05-01 16:51
Second Decision	2025-07-03 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-03 06:01
Articles in Press	2025-07-03 06:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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