Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	108418
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Retrospective Cohort Study
Article Title	Differential effects of the KRAS gene on recurrence in right- vs left-sided colorectal liver metastases undergoing radiofrequency ablation
Manuscript Source	Unsolicited Manuscript
All Author List	Bin-Bin Jiang, Ji-Chen Wang, Kun Yan, Zhong-Yi Zhang, Song Wang, Wei Wu and Wei Yang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82472002 Capital Health Development Research Project 2020-2-2152
Corresponding Author	Kun Yan, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China. ydbz@vip.sina.com
Key Words	Recurrence; Primary tumor location; Radiofrequency ablation; Colorectal cancer
Core Tip	The mutation status of the KRAS differentially impacts intrahepatic recurrence after radiofrequency ablation (RFA) for colorectal liver metastases (CLMs) based on primary tumor location. Patients with left-sided colorectal cancer harboring KRAS mutations have significantly worse intrahepatic recurrence-free survival post-RFA, whereas no such association exists in right-sided patients. KRAS status was not correlated with extrahepatic recurrence, regardless of tumor origin. These findings highlight the clinical value of incorporating both primary tumor location and KRAS genotyping to optimize post-RFA management strategies, enabling personalized approaches to reduce recurrence risk and improve long-term outcomes in CLM patients.
Citation	Jiang BB, Wang JC, Yan K, Zhang ZY, Wang S, Wu W, Yang W. Differential effects of the KRAS gene on recurrence in right- vs left-sided colorectal liver metastases undergoing radiofrequency ablation. World J Gastrointest Surg 2025; In press

Received	2025-04-14 09:17
Peer-Review Started	2025-04-14 09:17
To Make the First Decision
Return for Revision	2025-05-09 05:23
Revised	2025-05-20 03:16
Second Decision	2025-06-16 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-16 10:09
Articles in Press	2025-06-16 10:09
Publication Fee Transferred	2025-05-24 10:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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