Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	108455
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Genetic evidence for the causal influence of inflammatory factors on intrahepatic cholangiocarcinoma risk
Manuscript Source	Unsolicited Manuscript
All Author List	Bing Chen, Jun Chen, Zhi-Tao Chen, Zhang-Peng Feng, Han-Bei Lv and Guo-Ping Jiang
Funding Agency and Grant Number	Funding Agency Grant Number National Key Research and Development Program of China 2021YFA1301104
Corresponding Author	Guo-Ping Jiang, Assistant Professor, Associate Chief Physician, PhD, Department of Hepatobiliary Surgery, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, No. 848 Dongxin Raod, Hangzhou 310022, Zhejiang Province, China. guoping.jiang@shulan.com
Key Words	Intrahepatic cholangiocarcinoma; Mendelian randomization; Bayesian Weighted Mendelian Randomization; Inflammatory factors; Tumor microenvironment
Core Tip	This study investigates the causal role of inflammatory factors in the risk of intrahepatic cholangiocarcinoma (ICC) using Mendelian randomization and Bayesian Weighted Mendelian randomization analyses. Elevated levels of artemin and matrix metalloproteinase-10 were significantly associated with increased ICC risk, suggesting their potential as risk factors and therapeutic targeting. These results highlight the crucial role of inflammatory factors within the tumor microenvironment in ICC development, offering new insights for targeted interventions.
Citation	Chen B, Chen J, Chen ZT, Feng ZP, Lv HB, Jiang GP. Genetic evidence for the causal influence of inflammatory factors on intrahepatic cholangiocarcinoma risk. World J Gastrointest Oncol 2025; In press

Received	2025-04-14 09:01
Peer-Review Started	2025-04-14 09:01
To Make the First Decision
Return for Revision	2025-04-22 12:24
Revised	2025-04-30 15:09
Second Decision	2025-06-16 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-16 08:21
Articles in Press	2025-06-16 08:21
Publication Fee Transferred	2025-05-06 10:29
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Typeset the Manuscript

ISSN	1948-5204 (online)
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