Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	108470
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Retrospective Cohort Study
Article Title	Efficacy of adjuvant chemotherapy in stage II colon cancer patients with twelve or more lymph nodes retrieve
Manuscript Source	Unsolicited Manuscript
All Author List	Yu Huo, Yue-Yang Zhang, Shuai Jiao, Zhong-Yuan Bai, Wen-Qi Bai, Hai-Tao Zhou and Xu Guan
Funding Agency and Grant Number	Funding Agency Grant Number Shanxi Special Projects of the Central Government Guiding Local Science and Technology Development of China YDZJSX2021B016 Shanxi Cancer Hospital Doctoral Master's Guide and Companion Flying Fund SD2023010
Corresponding Author	Wen-Qi Bai, Department of General Surgery Sciences, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, No. 3 Xinghualing District Workers’ New Village, Taiyuan 030000, Shanxi Province, China. baiwenqi1998@163.com
Key Words	Stage II; Colon cancer; Lymph nodes; Chemotherapy; Prognosis
Core Tip	No adjuvant chemotherapy (ACT) continues to be a significant independent predictor for patients with stage II colon cancer who have 12 or more lymph nodes (LNs) removed. Even among these patients with T3 stage and grade 1/2, ACT still leads to improved prognosis. Based on two large-scale population-based cohorts and the propensity score matching method, we validated the generalizability and reliability of these findings. This research confirms that patients with adequate LNs retrieval (≥ 12 LNs) can still benefit from ACT, which is expected to provide valuable insights and further guide clinical practice in the management of colorectal carcinoma.
Citation	Huo Y, Zhang YY, Jiao S, Bai ZY, Bai WQ, Zhou HT, Guan X. Efficacy of adjuvant chemotherapy in stage II colon cancer patients with twelve or more lymph nodes retrieve. World J Gastrointest Oncol 2025; In press

Received	2025-04-15 11:12
Peer-Review Started	2025-04-15 11:12
To Make the First Decision
Return for Revision	2025-05-15 12:00
Revised	2025-05-26 10:31
Second Decision	2025-07-25 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-25 06:55
Articles in Press	2025-07-25 06:55
Publication Fee Transferred	2025-05-28 10:33
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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