Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	108514
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Ulcerative colitis and colorectal cancer: Pathogenic insights and precision strategies for prevention and treatment
Manuscript Source	Invited Manuscript
All Author List	Martina Catalano, Enrico Mini, Stefania Nobili, Ismaela Anna Vascotto, Delia Ravizza, Andrea Amorosi, Francesco Tonelli, Franco Roviello, Giandomenico Roviello and Gabriella Nesi
Funding Agency and Grant Number
Corresponding Author	Giandomenico Roviello, Associate Professor, MD, PhD, Department of Health Sciences, University of Florence, viale Pieraccini, 6, Florence 50134, Tuscany, Italy. giandomenico.roviello@unifi.it
Key Words	Ulcerative colitis; Colorectal cancer; Prevention; Surveillance; Treatment
Core Tip	Ulcerative colitis is a chronic inflammatory bowel disease with increased risk of colorectal cancer (CRC), particularly colitis-associated CRC (caCRC). The development of caCRC is influenced by disease duration, extent, severity, and factors such as primary sclerosing cholangitis and family history. Unlike sporadic CRC, caCRC tends to occur at a younger age and follows a distinct inflammation-dysplasia-carcinoma sequence. This review highlights the pathogenic link between ulcerative colitis and CRC and summarizes current strategies for prevention, surveillance, and management to improve patient outcomes.
Citation	Catalano M, Mini E, Nobili S, Vascotto IA, Ravizza D, Amorosi A, Tonelli F, Roviello F, Roviello G, Nesi G. Ulcerative colitis and colorectal cancer: Pathogenic insights and precision strategies for prevention and treatment. World J Gastrointest Oncol 2025; In press

Received	2025-04-16 06:37
Peer-Review Started	2025-04-16 06:37
To Make the First Decision
Return for Revision	2025-04-24 21:00
Revised	2025-05-28 10:26
Second Decision	2025-08-14 03:14
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-15 03:52
Articles in Press	2025-08-15 03:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com