Publication Name	World Journal of Stem Cells
Manuscript ID	108519
Country	United States

Category	Dermatology
Manuscript Type	Systematic Reviews
Article Title	Therapeutic potential of stem cells-derived exosomes in hair regeneration: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Neil Poddar, Adarsh Aratikatla and Ashim Gupta
Funding Agency and Grant Number
Corresponding Author	Ashim Gupta, PhD, President, Professor, Department of Orthopaedics and Regenerative Medicine, Future Biologics, 2505 Newpoint Pkwy, Lawrenceville, GA 30043, United States. ashim6786@gmail.com
Key Words	Alopecia; Hair loss; Hair regeneration; Stem cells; Exosomes; Extracellular vesicles; Secretome; Regenerative medicine
Core Tip	This review synthesizes findings from in vitro, preclinical, and clinical studies to evaluate the efficacy, mechanisms, and challenges associated with exosome-based hair restoration therapies. Twenty seven studies met our pre-defined search and inclusion criteria and were included in this review. Exosome-based therapies hold immense promise for hair regeneration by leveraging their ability to modulate key signaling pathways and enhance hair follicle regeneration. While in vitro and preclinical studies demonstrate consistent efficacy across diverse exosome sources, methodological heterogeneity and limited number of clinical studies warrant further clinical research to realize their full clinical potential for hair regeneration.
Citation	Poddar N, Aratikatla A, Gupta A. Therapeutic potential of stem cells-derived exosomes in hair regeneration: A systematic review. World J Stem Cells 2025; In press

Received	2025-04-16 06:40
Peer-Review Started	2025-04-16 06:40
To Make the First Decision
Return for Revision	2025-05-15 12:34
Revised	2025-05-27 07:12
Second Decision	2025-06-13 10:32
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-16 10:21
Articles in Press	2025-06-16 10:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
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