Publication Name	World Journal of Nephrology
Manuscript ID	108534
Country	Jordan

Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	Adipose-derived mesenchymal stromal cell secretome protects against kidney injury through induction of HO-1 upregulation in vitro
Manuscript Source	Unsolicited Manuscript
All Author List	Hanan Jafar, Nidaa A Ababneh, Dana Alhattab, Renata M Alatoom, Suzan Zalloum, Bareqa Salah, Hussein Alhawari and Abdalla Awidi
Funding Agency and Grant Number	Funding Agency Grant Number Abdul Hameed Shoman Foundation (AHSF) 6/2018
Corresponding Author	Abdalla Awidi, Cell Therapy Center, The University of Jordan, Queen Rania St, Amman 11942, Amman, Jordan. aabbadi@ju.edu.jo
Key Words	Renal tubular epithelial cells; Secretome; HO-1 upregulation; Oxidative stress; Mesenchymal stromal cells; Acute kidney injury
Core Tip	This study highlights the therapeutic potential of secretome derived from adipose-derived mesenchymal stromal cells (ADMSCs) in protecting renal tubular epithelial cells under oxidative stress conditions. The ADMSC secretome reduced reactive oxygen species levels, enhanced mitochondrial membrane potential, and upregulated heme oxygenase-1 gene expression, indicating activation of cytoprotective pathways. Comparative transcriptome analysis with bone marrow-derived mesenchymal stromal cells revealed distinct gene expression profiles related to mitochondrial and antioxidant functions. These findings support the use of ADMSC secretome as a promising cell-free approach for mitigating oxidative damage in acute kidney injury.
Citation	Jafar H, Ababneh NA, Alhattab D, Alatoom RM, Zalloum S, Salah B, Alhawari H, Awidi A. Adipose-derived mesenchymal stromal cell secretome protects against kidney injury through induction of HO-1 upregulation in vitro. World J Nephrol 2025; In press

Received	2025-04-17 02:55
Peer-Review Started	2025-04-17 02:56
To Make the First Decision
Return for Revision	2025-05-15 08:45
Revised	2025-05-29 08:35
Second Decision	2025-07-14 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-15 08:07
Articles in Press	2025-07-15 08:07
Publication Fee Transferred	2025-06-04 13:24
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
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