Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	108578
Country	Türkiye

Category	Oncology
Manuscript Type	Editorial
Article Title	Changing patterns of cholangiocarcinoma and gallbladder cancer: A regional perspective from Northeastern Italy
Manuscript Source	Invited Manuscript
All Author List	Duygu Kirkik, Ayse Naz Ozabaci and Sevgi Kalkanli Tas
Funding Agency and Grant Number
Corresponding Author	Duygu Kirkik, Assistant Professor, PhD, Department of Immunology, Hamidiye Medicine Faculty, University of Health Sciences, Mekteb-i Tıbbiyye-i Şâhane (Haydarpaşa) Külliyesi Selimiye Mah Tıbbiye Cad No. 38, Istanbul 34668, Türkiye. dygkirkik@gmail.com
Key Words	Cholangiocarcinoma; Gallbladder cancer; Epidemiology; Intrahepatic cholangiocarcinoma; Extrahepatic cholangiocarcinoma
Core Tip	Cholangiocarcinoma (CCA) is an aggressive biliary tract malignancy with rising incidence, particularly of intrahepatic CCA, in many regions worldwide. Despite its relatively low overall incidence, CCA poses a major public health concern due to late diagnosis and poor prognosis. This study highlights shifting epidemiological trends over a 17-year period in Northeastern Italy, emphasizing declining hospitalization rates for both intrahepatic and extrahepatic CCA, despite global projections of increased incidence and mortality. The findings underscore the importance of ongoing, population-based surveillance to evaluate evolving risk patterns, sex- and age-related disparities, and regional healthcare responses - essential for guiding future preventive and diagnostic strategies.
Citation	Kirkik D, Ozabaci AN, Kalkanli Tas S. Changing patterns of cholangiocarcinoma and gallbladder cancer: A regional perspective from Northeastern Italy. World J Gastrointest Oncol 2025; In press

Received	2025-04-18 05:09
Peer-Review Started	2025-04-18 05:09
To Make the First Decision
Return for Revision	2025-05-13 12:02
Revised	2025-05-22 08:00
Second Decision	2025-07-21 02:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-21 08:49
Articles in Press	2025-07-21 08:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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