Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	108600
Country	Taiwan

Category	Oncology
Manuscript Type	Observational Study
Article Title	Morphomics in esophageal cancer: Validation and association with muscular and cardiorespiratory fitness
Manuscript Source	Unsolicited Manuscript
All Author List	Watson Hua-Sheng Tseng, Shu-Chun Huang, Stewart C Wang, Jules Lin, Peng Zhang, Yu-Chen Liu, Yin-Kai Chao and Chien-Hung Chiu
Funding Agency and Grant Number	Funding Agency Grant Number Chang Gung Memorial Hospital CMRPG3N1171 and CMRPG3N1172 Chang Gung Memorial Hospital CORPVVN0071, CMRPVVK0111-3 and CMRPVVL0121-3 National Science and Technology Council, Taiwan MOST 113-2314-B-182A-094-
Corresponding Author	Chien-Hung Chiu, Assistant Professor, MD, Division of Thoracic Surgery, Chang Gung Memorial Hospital, 5 Fu-Shing St. Kwei-Shan, Taoyuan 33305, Taiwan. happy9000000@gmail.com
Key Words	Morphomics; Body composition; Bioelectrical impedance analysis; Hand grip strength; Cardiopulmonary exercise testing; Computed tomography
Core Tip	This study explored the relationship between computed tomography-based morphomics and physical assessments, including bioelectrical impedance analysis, hand grip strength, and cardiopulmonary exercise testing in esophageal cancer patients. Morphomics at the eleventh thoracic vertebra level had the most complete data and showed strong correlations with muscle mass, strength, and exercise capacity. Fat measurements from morphomics were inversely related to exercise performance. Morphomics also demonstrated potential to identify patients with low cardiorespiratory fitness, highlighting its clinical potential as a reliable tool for assessing physical fitness and guiding personalized care in esophageal cancer.
Citation	Tseng WHS, Huang SC, Wang SC, Lin J, Zhang P, Liu YC, Chao YK, Chiu CH. Morphomics in esophageal cancer: Validation and association with muscular and cardiorespiratory fitness. World J Gastrointest Surg 2025; In press

Received	2025-04-18 03:01
Peer-Review Started	2025-04-18 03:01
To Make the First Decision
Return for Revision	2025-05-09 05:22
Revised	2025-05-22 03:40
Second Decision	2025-06-23 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-23 06:56
Articles in Press	2025-06-23 06:56
Publication Fee Transferred	2025-05-23 20:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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