Publication Name	World Journal of Gastroenterology
Manuscript ID	108662
Country	China

Category	Immunology
Manuscript Type	Basic Study
Article Title	Histone deacetylases 10 as a prognostic biomarker correlates with tumor microenvironment and therapy response in colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Hai-Hang Nie, Xue-Ying Yang, Jing-Kai Zhou, Gui-Lin Gao, Lu Ding, Yun-Tian Hong, Ya-Li Yu, Pei-Shan Qiu, Zi-Yue Zeng, Jun Lai, Ting Zheng, Hai-Zhou Wang, Qiu Zhao and Fan Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82403279 and 82303181
Corresponding Author	Fan Wang, Department of Gastroenterology, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuhan 430070, Hubei Province, China. 2020283030092@whu.edu.cn
Key Words	Histone deacetylases 10; Colorectal cancer; Tumor microenvironment; Immunotherapy; Prognosis
Core Tip	Histone deacetylases 10 (HDAC10), a HDAC family member, was overexpressed in colorectal cancer (CRC) and associated with poor prognosis. HDAC10 depletion inhibited CRC cell proliferation and migration, suggesting its oncogenic role. Gene set variation analysis linked elevated HDAC10 expression to immunosuppressive pathways and a non-inflamed tumor microenvironment (TME), characterized by reduced immune cell infiltration. CRC patients with high HDAC10 levels showed reduced sensitivity to immunotherapy, indicating therapeutic resistance. Our findings highlight HDAC10’s critical role in shaping the TME, treatment response, and clinical outcomes in CRC, supporting its potential as a therapeutic target to improve CRC management.
Citation	Nie HH, Yang XY, Zhou JK, Gao GL, Ding L, Hong YT, Yu YL, Qiu PS, Zeng ZY, Lai J, Zheng T, Wang HZ, Zhao Q, Wang F. Histone deacetylases 10 as a prognostic biomarker correlates with tumor microenvironment and therapy response in colorectal cancer. World J Gastroenterol 2025; In press

Received	2025-04-21 03:42
Peer-Review Started	2025-04-21 03:42
To Make the First Decision
Return for Revision	2025-05-10 18:01
Revised	2025-05-18 02:45
Second Decision	2025-06-12 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-12 07:01
Articles in Press	2025-06-12 07:01
Publication Fee Transferred	2025-05-20 01:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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