Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	108672
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	DEAD/H-box RNA helicase 10 promotes pancreatic cancer cell proliferation via ribonucleotide reductase M2
Manuscript Source	Unsolicited Manuscript
All Author List	Zhi-Sheng Qiu, Xiao-Chun Wang, Ji-Chun Ma, Cheng-Lou Zhu, Yong-Li Hu and Ming-Xu Da
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82160588 Health Commission of Gansu Province GSWSKY2021-032 Natural Science Foundation of Gansu Province 24JRRA585 Gansu Provincial Hospital Science and Technology innovation platform fund project 21GSSYB-23
Corresponding Author	Ming-Xu Da, Professor, The First Clinical Medical College, Lanzhou University, No. 222 Tianshui South Road, Chengguan District, Lanzhou 730000, Gansu Province, China. ldyy_damx@lzu.edu.cn
Key Words	RRM2; DEAD-box RNA helicase 10; Pancreatic cancer proliferation; Migration; Invasion
Core Tip	This study elucidates the role of DEAD-box RNA helicase 10 (DDX10) in pancreatic cancer (PC) progression. Through bioinformatics analysis, tissue microarray evaluation, and in vitro assays, we discovered that DDX10 is overexpressed in PC tissues compared to non-tumor tissues. Knockdown of DDX10 significantly inhibited cell proliferation, invasion, and migration while promoting apoptosis. Mechanistic investigations revealed that DDX10 regulates key oncogenes, including RRM2, which counteracts the growth-inhibitory effects of DDX10 knockdown. Importantly, DDX10 expression was found to negatively correlate with patient survival rates. These findings highlight DDX10 as a potential therapeutic target for PC.
Citation	Qiu ZS, Wang XC, Ma JC, Zhu CL, Hu YL, Da MX. DEAD/H-box RNA helicase 10 promotes pancreatic cancer cell proliferation via ribonucleotide reductase M2. World J Gastrointest Oncol 2025; In press

Received	2025-04-21 05:15
Peer-Review Started	2025-04-21 05:16
To Make the First Decision
Return for Revision	2025-05-13 12:07
Revised	2025-05-23 08:58
Second Decision	2025-07-18 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-18 08:12
Articles in Press	2025-07-18 08:12
Publication Fee Transferred	2025-05-26 15:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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