Publication Name	World Journal of Psychiatry
Manuscript ID	108712
Country	China

Category	Psychiatry
Manuscript Type	Retrospective Study
Article Title	Anxiety and depression in patients with hepatobiliary and pancreatic malignancies: Influence of disease stage and psychosocial factors
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao Yu, Xiao He and Shuai Wang
Funding Agency and Grant Number
Corresponding Author	Shuai Wang, PhD, Department of Hepatobiliary Surgery, Jingzhou Hospital Affiliated to Yangtze University, Chuyuan Avenue, Jingzhou District, Jingzhou 434020, Hubei Province, China. l10095@yangtzeu.edu.cn
Key Words	Hepatobiliary and pancreatic malignancies; Anxiety; Depression; Comorbidity; Psychological factors; Clinical characteristics
Core Tip	Patients with hepatobiliary and pancreatic malignancies often experience comorbid anxiety and depression; however, the association between disease stage and psychological status remains unclear. This study uniquely compared early-stage (IA-IB) and intermediate-stage (IIA-IIIA) patients with healthy controls. Significantly higher anxiety detection rates and life event scores were observed in intermediate-stage patients, highlighting disease progression as a key burden. We propose integrating psychological interventions into comprehensive cancer care to enhance treatment efficacy and quality of life.
Citation	Yu X, He X, Wang S. Anxiety and depression in patients with hepatobiliary and pancreatic malignancies: Influence of disease stage and psychosocial factors. World J Psychiatry 2025; In press

Received	2025-06-24 08:23
Peer-Review Started	2025-06-24 08:23
To Make the First Decision
Return for Revision	2025-07-17 08:32
Revised	2025-07-25 13:30
Second Decision	2025-08-11 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-13 10:18
Articles in Press	2025-08-13 10:18
Publication Fee Transferred	2025-07-29 13:52
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com