Publication Name	World Journal of Virology
Manuscript ID	108754
Country	United States

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Systematic Reviews
Article Title	Hepatitis C virus-associated cardiomyopathy: A review of pathogenesis
Manuscript Source	Invited Manuscript
All Author List	Inderjeet Singh Bharaj, Gurkaranvir Singh, Ajit Singh Brar, Aayushi Kacheria, Jasraj Kahlon, Billal Mohmand, Aalam Sohal and Beeletsega T Yeneneh
Funding Agency and Grant Number
Corresponding Author	Aalam Sohal, Department of Gastroenterology and Hepatology, Creighton University School of Medicine, 3216 NE 45th Pl Suite 212, Phoenix, AZ 85012, United States. aalamsohal@gmail.com
Key Words	Hepatitis C virus; Cardiomyopathy; Direct-acting antivirals; Cirrhosis; Cardiotropic
Core Tip	Chronic hepatitis C virus (HCV) infection is emerging as a significant contributor to cardiomyopathy, including dilated, hypertrophic, and arrhythmogenic subtypes. This review synthesizes evidence outlining complex pathogenic mechanisms: Direct viral toxicity via HCV core protein–mediated cytokine release (e.g., tumor necrosis factor alpha), immune-mediated damage, genetic predispositions, apoptotic pathways, and cirrhotic cardiomyopathy from HCV-induced liver disease. Notably, direct-acting antiviral (DAA) therapies not only achieve high cure rates but also improve cardiac function, although potential cardiotoxic effects require vigilance. The study underscores the need for further research into mechanistic insights, biomarker validation, and expanding global DAA access to mitigate cardiovascular risks to improve patient outcomes.
Citation	Bharaj IS, Singh G, Brar AS, Kacheria A, Kahlon J, Mohmand B, Sohal A, Yeneneh BT. Hepatitis C virus-associated cardiomyopathy: A review of pathogenesis. World J Virol 2025; In press

Received	2025-04-22 13:16
Peer-Review Started	2025-04-22 13:17
To Make the First Decision
Return for Revision	2025-05-30 03:41
Revised	2025-06-10 22:15
Second Decision	2025-08-27 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-27 10:24
Articles in Press	2025-08-27 10:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3249 (online)
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