Publication Name	World Journal of Hepatology
Manuscript ID	108772
Country	India

Category	Public, Environmental & Occupational Health
Manuscript Type	Review
Article Title	Toxins to treatments: Impact of environmental pollutants, gut microbiota, and natural compounds on non-alcoholic fatty liver disease progression
Manuscript Source	Invited Manuscript
All Author List	Tanvi Sharma, Naveen Kaushal and Roobee Garla
Funding Agency and Grant Number	Funding Agency Grant Number DHR Women Scientist Fellowship 12013/53/2024
Corresponding Author	Roobee Garla, PhD, Post Doctoral Researcher, Department of Biophysics, Panjab University, Department of Biophysics, Panjab University, Chandigarh, 160014, India. rubygarla@yahoo.co.in., CHANDIGARH 160014, CHANDIGARH, India. rubygarla@yahoo.co.in
Key Words	Non-alcoholic fatty liver disease; Gut microbiome; Environmental pollutant; Selenium; Short-chain fatty acids
Core Tip	A combination of factors, such as nutrition, oxidative stress, inflammation, gut dysbiosis, and heredity, causes a complicated metabolic disease, NAFLD. Environmental pollutants are becoming more prominent factors in its development. In this review, we will be discussing the treatment regimens that incorporate genetic, microbiological, and metabolic characteristics that are essential. Along with lifestyle changes, new approaches like microbiota-targeted treatments and selenium supplementation show promise but require more research. To create accurate and efficient therapies for the prevention and management of NAFLD, future research should prioritize early screening, particularly in high-risk groups, and concentrate on the dynamics of the gut-liver axis.
Citation	Sharma T, Kaushal N, Garla R. Toxins to treatments: Impact of environmental pollutants, gut microbiota, and natural compounds on non-alcoholic fatty liver disease progression. World J Hepatol 2025; In press

Received	2025-04-22 13:15
Peer-Review Started	2025-04-24 00:03
To Make the First Decision
Return for Revision	2025-05-28 09:45
Revised	2025-06-06 13:07
Second Decision	2025-07-21 03:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-22 01:29
Articles in Press	2025-07-22 01:29
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ISSN	1948-5182 (online)
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