Publication Name	World Journal of Diabetes
Manuscript ID	108789
Country	South Africa

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Decoding androgen excess in polycystic ovary syndrome: Roles of insulin resistance and other key intraovarian and systemic factors
Manuscript Source	Invited Manuscript
All Author List	Neervana Rambaran and Md Shahidul Islam
Funding Agency and Grant Number	Funding Agency Grant Number Research Office of the University of KwaZulu-Natal, Durban, South Africa National Research Foundation, Pretoria, South Africa 145943
Corresponding Author	Md Shahidul Islam, Full Professor, Head, PhD, Professor, Senior Scientist, Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, University Road, Chiltern Hills, Durban 4000, KwaZulu-Natal, South Africa. islamd@ukzn.ac.za
Key Words	Polycystic ovary syndrome; Hyperandrogenism; Insulin resistance; Oxidative stress; Obesity; Folliculogenesis; Ovary
Core Tip	Polycystic ovary syndrome is a multifactorial disorder characterized by excess ovarian androgen production, frequently amplified by insulin resistance. This study explores how insulin resistance intersects with systemic and intraovarian factors such as activin, inhibin, follistatin, anti-Mullerian hormone, bone morphogenetic proteins, growth differentiation factor-9 and Kit ligand, as well as the dysregulation in both the insulin and the transforming growth factor-β superfamily signaling pathway, to create a vicious cycle of reproductive and metabolic dysfunction. A deeper understanding of these factors and pathways emphasizes the need for individualized, multi-targeted therapeutic approaches beyond conventional treatments.
Citation	Rambaran N, Islam MS. Decoding androgen excess in polycystic ovary syndrome: Roles of insulin resistance and other key intraovarian and systemic factors. World J Diabetes 2025; In press

Received	2025-04-23 03:54
Peer-Review Started	2025-04-24 09:19
To Make the First Decision
Return for Revision	2025-05-07 04:00
Revised	2025-05-19 21:55
Second Decision	2025-06-23 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-23 09:08
Articles in Press	2025-06-23 09:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com