Publication Name	World Journal of Transplantation
Manuscript ID	108806
Country	Pakistan

Category	Transplantation
Manuscript Type	Minireviews
Article Title	Critical role of complement in antibody mediated rejection in kidney transplantation
Manuscript Source	Invited Manuscript
All Author List	Khawar Abbas, Muhammed Mubarak, Wajiha Musharraf, Tahir Aziz and Mirza Naqi Zafar
Funding Agency and Grant Number
Corresponding Author	Khawar Abbas, Professor, Department of Transplant Immunology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi 74200, Sind, Pakistan. drkhawar_imuno@yahoo.com
Key Words	Complement; Donor-specific antibodies; Kidney; Allograft; Rejection; Graft failure
Core Tip	Antibody-mediated rejection (AMR) is a significant barrier to successful kidney transplantation, driven primarily by donor-specific alloantibodies. These antibodies activate complement pathways within the transplanted kidney, leading to severe inflammatory responses, endothelial injury, and tissue damage. Understanding the complement system’s critical role in AMR has led to innovative therapies aimed at inhibiting complement activation. Such complement-targeted strategies show potential in reducing inflammation, preventing graft injury, and improving overall graft survival. This review highlights the central contribution of complement activation in AMR, emphasizing therapeutic advancements and the importance of complement inhibition as a promising approach for preventing and managing rejection.
Citation	Abbas K, Mubarak M, Musharraf W, Aziz T, Zafar MN. Critical role of complement in antibody mediated rejection in kidney transplantation. World J Transplant 2025; In press

Received	2025-04-24 05:27
Peer-Review Started	2025-04-24 05:27
To Make the First Decision
Return for Revision	2025-05-09 13:14
Revised	2025-05-12 16:42
Second Decision	2025-07-25 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-25 08:53
Articles in Press	2025-07-25 08:53
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ISSN	2220-3230 (online)
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