Publication Name	World Journal of Clinical Oncology
Manuscript ID	108819
Country	Italy

Category	Biology
Manuscript Type	Review
Article Title	Unraveling the links between estrogen and gut microbiota in sex-hormone driven cancers
Manuscript Source	Invited Manuscript
All Author List	Amal Tahri and Amedeo Amedei
Funding Agency and Grant Number
Corresponding Author	Amedeo Amedei, Department of Experimental and Clinical Medicine, University of Florence, 3 Largo Brambilla, Florence 50134, Italy. amedeo.amedei@unifi.it
Key Words	Diet; Prostate; Breast; Estrobolome; Cancer; Gut microbiome; Estrogen
Core Tip	The effect of the gut microbiome (GM) expands upon the intestine in altering the metabolism and inducing inflammation. Mutually, the host microenvironment impacts the GM through the variation of estrogen levels. The circulating estrogen itself is regulated through the β-glucuronidase enzyme which deconjugates estrogen to its biologically active form, allowing it to link to estrogen receptors and thus contributing to its physiological and pathological effects (e.g. cancers and specially sex-hormone driven cancers). In this review, the interaction between estrogen and microbiota in sex-hormone-mediated cancers as well as the potential health outcomes on their clinical management are emphasized.
Citation	Tahri A, Amedei A. Unraveling the links between estrogen and gut microbiota in sex-hormone driven cancers. World J Clin Oncol 2025; In press

Received	2025-04-24 06:49
Peer-Review Started	2025-04-24 06:49
To Make the First Decision
Return for Revision	2025-05-17 07:35
Revised	2025-05-28 10:48
Second Decision	2025-08-07 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-08 10:13
Articles in Press	2025-08-08 10:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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