Publication Name	World Journal of Hepatology
Manuscript ID	108845
Country	Mexico

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Duodenal mucosal ablation by irreversible electroporation: Modulating the gut-liver axis in metabolic steatotic liver disease
Manuscript Source	Invited Manuscript
All Author List	Mariana M Ramírez-Mejía and Nahum Méndez-Sánchez
Funding Agency and Grant Number
Corresponding Author	Nahum Méndez-Sánchez, AGAF, FAASLD, FACG, MD, PhD, Liver Research Unit, Medica Sur Clinic and Foundation, Puente de Piedra 150, Col. Toriello Guerra, Mexico City 14050, Mexico. nah@unam.mx
Key Words	Gut‒Liver Axis; Metabolic dysfunction-associated steatotic liver disease; Duodenal mucosa ablation; Intestinal permeability; Lipids
Core Tip	Duodenal mucosal ablation (DMA) via irreversible electroporation has emerged as a novel strategy to modulate the gut–liver axis in metabolic dysfunction-associated steatotic liver disease (MASLD). In this letter, we analyzed recent preclinical evidence from Yu et al, who reported that DMA leads to reduced hepatic steatosis, improved lipid profiles, and enhanced intestinal barrier integrity. We contextualize these findings within the physiology of the duodenum and explore their translational potential as a minimally invasive therapeutic approach in MASLD.
Citation	Ramírez-Mejía MM, Méndez-Sánchez N. Duodenal mucosal ablation by irreversible electroporation: Modulating the gut-liver axis in metabolic steatotic liver disease. World J Hepatol 2025; In press

Received	2025-04-25 10:57
Peer-Review Started	2025-04-25 10:57
To Make the First Decision
Return for Revision	2025-05-10 16:50
Revised	2025-05-22 00:56
Second Decision	2025-07-25 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-25 08:56
Articles in Press	2025-07-25 08:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com