| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Evaluating serum extra spindle pole bodies-like 1 protein vs p53 antibody for hepatitis B virus-related hepatocellular carcinoma diagnosis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Fei Feng, Hui-Kun Zhou, Bo-Bin Hu, Hang Wang, Heng-Kai Liang, Lu Wei, Qing-Mei Li, Tu-Mei Su, Qian-Bing Yin, Ming-Hua Su and Jian-Ning Jiang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81960115, No. 82160123 and No. 82260124 |
| Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education |
No. GKE-ZZ202107 |
| Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor |
No. GKE-ZZ202218 |
| Guangxi Science and Technology Program |
No. AD25069077 |
|
| Corresponding Author |
Jian-Ning Jiang, Chief Physician, MD, PhD, Professor, Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. gxjjianning@163.com |
| Key Words |
Extra spindle pole bodies-like 1; p53 antibody; Hepatocellular carcinoma; Hepatitis B virus; Diagnostic biomarker; Case-control study |
| Core Tip |
This study evaluates serum extra spindle pole bodies-like 1 (ESPL1) protein as a diagnostic biomarker for hepatitis B virus-related hepatocellular carcinoma (HBV-HCC), demonstrating superior sensitivity and accuracy compared to p53 antibody and alpha-fetoprotein (AFP). ESPL1 levels progressively increase from chronic hepatitis B to cirrhosis and HCC, correlating with disease progression. Mechanistically, ESPL1 overexpression due to HBV integration drives chromosomal instability, promoting oncogenesis. These findings support ESPL1 as a promising biomarker for early HBV-HCC detection. The study also suggests that ESPL1 may complement AFP in clinical settings, offering enhanced diagnostic reliability and supporting its potential as a novel candidate for HBV-HCC early detection. |
| Citation |
Feng YF, Zhou HK, Hu BB, Wang H, Liang HK, Wei L, Li QM, Su TM, Yin QB, Su MH, Jiang JN. Evaluating serum extra spindle pole bodies-like 1 protein vs p53 antibody for hepatitis B virus-related hepatocellular carcinoma diagnosis. World J Hepatol 2025; In press |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
