Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	108854
Country	Thailand

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Efficacy and palatability of the developed polyethylene glycol-based formula for the treatment of children with functional constipation
Manuscript Source	Invited Manuscript
All Author List	Duc Long Tran and Palittiya Sintusek
Funding Agency and Grant Number	Funding Agency Grant Number Chulalongkorn’s 90-year Scholarship Ratchdapisek Research Ratchadapiseksompotch Funds, Graduate Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand No. GA68/028
Corresponding Author	Palittiya Sintusek, MD, PhD, Center of Excellence in Thai Pediatric Gastroenterology, Hepatology and Immunology (TPGHAI), Division of Gastroenterology, Department of Pediatrics, King Chulalongkorn Memorial Hospital, Chulalongkorn University, 254 Phyathai Road, Bangkok 10330, Thailand. palittiya.s@chula.ac.th
Key Words	Constipation; Palatability; Compliance; Polyethylene glycol; Children
Core Tip	Functional constipation (FC), a common functional gastrointestinal disorder in children, affects the quality of life of these children and their families. A combination of osmotic laxatives and toilet training is essential for effective management. Although polyethylene glycol (PEG) is recommended as the first-line treatment, poor palatability often limits patient compliance. This randomized controlled trial compared a newly developed PEG-based formula with the commercialized product, with both formulas being effective and safe. A positive correlation between palatability and compliance was established. Improving taste may be the key to enhancing compliance and improving treatment outcomes in children with FC.
Citation	Tran DL, Sintusek P. Efficacy and palatability of the developed polyethylene glycol-based formula for the treatment of children with functional constipation. World J Clin Pediatr 2025; In press

Received	2025-04-25 10:41
Peer-Review Started	2025-04-25 10:41
To Make the First Decision
Return for Revision	2025-05-14 06:11
Revised	2025-05-28 03:26
Second Decision	2025-08-07 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-08 10:15
Articles in Press	2025-08-08 10:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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