Publication Name	World Journal of Psychiatry
Manuscript ID	108867
Country	China

Category	Psychology
Manuscript Type	Basic Study
Article Title	Sini-Suanzaoren decoction regulates mitochondrial biogenesis mediated by MT-SIRT1 in the treatment of insomnia rats
Manuscript Source	Unsolicited Manuscript
All Author List	Ru-Ting Li, Bi-Juan Lan, Zhuo-Yang Xiao, Qing-Huan Shi, Xin-Yi Chen and Feng Li
Funding Agency and Grant Number	Funding Agency Grant Number the Beijing Natural Science Foundation 7232289
Corresponding Author	Feng Li, PhD, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No.11 North Third Ring East Road, Chaoyang District, Beijing 102488, China. lifeng_bucm0610@126.com
Key Words	Sini-Suanzaoren decoction; MT-SIRT1-mediated; Mitochondrial biogenesis; Insomnia rats
Core Tip	This study pioneers the scientific validation of Sini-Suanzaoren decoction (SNSZRD) for insomnia by bridging traditional Chinese medicine (TCM) theory with mitochondrial pathophysiology. We identify 8 blood-brain barrier-penetrating components (e.g., senkyunolide G) that activate the MT-SIRT1 pathway, reversing neuronal mitochondrial dysfunction via dose-dependent upregulation of PPARγ coactivator-1α/nuclear respiratory factor-1/mitochondrial transcription factor A. Crucially, we decode TCM principles: "Soothing liver depression" corresponds to SIRT1 stabilization, while "nourishing heart-spirit" aligns with ATP-dependent synaptic repair. This work establishes SNSZRD as a multi-target mitochondrial regulator, offering novel biomarkers (hypothalamic ATP) and lead compounds for insomnia therapeutics.
Citation	Li RT, Lan BJ, Xiao ZY, Shi QH, Chen XY, Li F. Sini-Suanzaoren decoction regulates mitochondrial biogenesis mediated by MT-SIRT1 in the treatment of insomnia rats. World J Psychiatry 2025; In press

Received	2025-07-01 08:55
Peer-Review Started	2025-07-01 08:55
To Make the First Decision
Return for Revision	2025-07-23 06:37
Revised	2025-08-06 09:39
Second Decision	2025-09-19 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-19 07:45
Articles in Press	2025-09-19 07:45
Publication Fee Transferred	2025-08-07 03:41
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Typeset the Manuscript

ISSN	2220-3206 (online)
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