Publication Name	World Journal of Methodology
Manuscript ID	108875
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Methodological insights into fecal microbiota transplantation: Dissecting key approaches for success
Manuscript Source	Invited Manuscript
All Author List	Sandeep K Mundhra and Rakesh Kochhar
Funding Agency and Grant Number
Corresponding Author	Rakesh Kochhar, Professor, Department of Gastroenterology, Paras Hospital, Nehru Hospital, F-Block Ground Floor, Panchkula 134109, India. dr_kochhar@hotmail.com
Key Words	Fecal microbiota transplantation; Microbiome; Fecal microbiota transplantation methodology; Fecal microbiota transplantation challenges; Standardization of fecal microbiota transplantation
Core Tip	Fecal microbiota transplantation (FMT) is a promising therapy for restoring gut microbiota, with established success in recurrent Clostridioides difficile infection and emerging potential in dysbiosis-related diseases. Key methodological advancements, including improved donor screening, stool processing, and novel delivery methods like capsule-based formulations and live biotherapeutic products, have improved FMT’s safety and accessibility. Despite ongoing concerns about long-term safety and efficacy, future directions such as personalized FMT, synthetic microbiota, and microbiome engineering hold significant promise.
Citation	Mundhra SK, Kochhar R. Methodological insights into fecal microbiota transplantation: Dissecting key approaches for success. World J Methodol 2025; In press

Received	2025-04-24 14:27
Peer-Review Started	2025-05-04 01:28
To Make the First Decision
Return for Revision	2025-05-17 15:13
Revised	2025-06-14 19:38
Second Decision	2025-09-03 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-03 08:04
Articles in Press	2025-09-03 08:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2222-0682 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com