Publication Name	World Journal of Critical Care Medicine
Manuscript ID	108907
Country	Australia

Category	Critical Care Medicine
Manuscript Type	Retrospective Cohort Study
Article Title	Predictive accuracy of 4C Mortality Score and Acute Physiology and Chronic Health Evaluation scores for mortality in COVID-19 patients admitted to intensive care unit
Manuscript Source	Invited Manuscript
All Author List	Kush Deshpande and Dushyant Tripathi
Funding Agency and Grant Number
Corresponding Author	Kush Deshpande, Consultant, MD, Department of Intensive Care, St George Hospital, Gray Street, Kogarah, NSW 2217, Sydney 2217, New South Wales, Australia. kush.deshpande@health.nsw.gov.au
Key Words	COVID-19; Mortality; Prediction scores; Acute Physiology and Chronic Health Evaluation II; Acute Physiology and Chronic Health Evaluation III; 4C Mortality Score
Core Tip	This retrospective cohort study compared the predictive accuracy of the 4C Mortality Score and Acute Physiology and Chronic Health Evaluation (APACHE) II and III scores for coronavirus disease 2019 patients admitted to intensive care unit (ICU). The 4C score at intensive care unit admission showed an area under the receiver operating characteristic curve of 0.80, higher than at hospital admission (0.75) and comparable to APACHE III (0.79) and II (0.75). Non-survivors were older, predominantly male, with more comorbidities and higher intervention rates. The study suggests that the 4C score at ICU admission is a reliable predictor of mortality and is easier to calculate. These findings warrant further validation in a larger study.
Citation	Deshpande K, Tripathi D. Predictive accuracy of 4C Mortality Score and Acute Physiology and Chronic Health Evaluation scores for mortality in COVID-19 patients admitted to intensive care unit. World J Crit Care Med 2025; In press

Received	2025-04-27 05:29
Peer-Review Started	2025-04-27 05:29
To Make the First Decision
Return for Revision	2025-05-20 08:38
Revised	2025-06-02 08:37
Second Decision	2025-08-29 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-29 06:59
Articles in Press	2025-08-29 06:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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