Publication Name	World Journal of Clinical Oncology
Manuscript ID	108967
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Untargeted metabolomics analysis of serum metabolic signatures as novel biomarkers for gastric carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Le Ren, Jun Liu, Ya-Yun Xu and Zhen-Wang Shi
Funding Agency and Grant Number
Corresponding Author	Zhen-Wang Shi, Professor, Department of Gastroenterology, Second People’s Hospital of Hefei, Heping Road, Hefei 230011, Anhui Province, China. shiyitao99@163.com
Key Words	Gastric carcinoma; Untargeted metabolomics; Serum; Biomarker; Diagnosis
Core Tip	We applied untargeted metabolomics to explore serum metabolic profile changes to identify potential serum biomarkers for the diagnosis of gastric carcinoma (GC). Firstly, a substantial alteration in the metabolic profile was observed. Secondly, the serum concentrations of eight metabolites were significantly elevated in 50 GC patients compared to 50 healthy controls. Thirdly, the area under the curve values for eight metabolites exceeded 0.7, indicating their effectiveness in distinguishing GC patients. Fourthly, the serum concentrations of methyclothiazide and epigallocatechin gallate demonstrated a positive correlation with T and N stage, while the serum concentrations of dimethenamid showed a positive correlation with T stage in GC patients.
Citation	Ren L, Liu J, Xu YY, Shi ZW. Untargeted metabolomics analysis of serum metabolic signatures as novel biomarkers for gastric carcinoma. World J Clin Oncol 2025; In press

Received	2025-04-27 16:06
Peer-Review Started	2025-04-27 16:07
To Make the First Decision
Return for Revision	2025-05-12 10:04
Revised	2025-05-14 13:22
Second Decision	2025-06-26 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-26 06:46
Articles in Press	2025-06-26 06:46
Publication Fee Transferred	2025-05-15 06:57
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Typeset the Manuscript

ISSN	2218-4333 (online)
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