Publication Name	World Journal of Cardiology
Manuscript ID	108975
Country	China

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Clinical application and expansion of paclitaxel-coated balloons in coronary atherosclerotic disease
Manuscript Source	Invited Manuscript
All Author List	A-Xiu Huang, Hong-Ying Xie, Gang Luo, Le Hong, Yun-Long Zhou, Yun Wang and De-Kui Gao
Funding Agency and Grant Number	Funding Agency Grant Number Mianyang Health Commission 2019 Scientific Research Encouragement Project 201948
Corresponding Author	De-Kui Gao, Department of Cardiology, Jiangyou Second People's Hospital, No. 31 Juhui Road, Jiangyou 621701, Sichuan Province, China. 635651229@qq.com
Key Words	Drug-coated balloon; Coronary artery disease; In-stent restenosis; Bifurcation lesion; Large blood vessel; Small blood vessel; Coronary artery dissection; Complication; Interventional treatment
Core Tip	Drug-coated balloon (DCB) angioplasty plays a pivotal role in the interventional management of atherosclerotic cardiovascular disease. This review focuses on the application of paclitaxel DCBs in coronary artery stenosis, encompassing their use in in-stent restenosis, large or small vessel disease, bifurcation lesions, and other lesion types. Key topics include lesion preparation techniques, DCB delivery strategies, complication management, safety evaluations, and post-procedural dual antiplatelet therapy strategies. Additionally, the review explores cellular and molecular mechanisms underlying anti-atherosclerotic and anti-restenotic effects, including endothelial repair, inhibition of neointimal hyperplasia, and modulation of inflammatory pathways. Current challenges and future directions in optimizing DCB-based therapies are also discussed.
Citation	Huang AX, Gao DK, Xie HY, Luo G, Hong L, Zhou YL, Wang Y. Clinical application and expansion of paclitaxel-coated balloons in coronary atherosclerotic disease. World J Cardiol 2025; In press

Received	2025-04-30 07:54
Peer-Review Started	2025-04-30 07:54
First Decision by Editorial Office Director	2025-05-17 08:49
Return for Revision	2025-05-17 08:49
Revised	2025-05-30 02:32
Publication Fee Transferred
Second Decision by Editor	2025-12-01 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-03 09:13
Articles in Press	2025-12-03 09:13
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com