Publication Name	World Journal of Transplantation
Manuscript ID	108982
Country	Italy

Category	Health Care Sciences & Services
Manuscript Type	Review
Article Title	Obinutuzumab in kidney transplantation: Past, present, and future
Manuscript Source	Invited Manuscript
All Author List	Evaldo Favi and Marika Morabito
Funding Agency and Grant Number
Corresponding Author	Evaldo Favi, MD, PhD, Department of General Surgery and Kidney Transplantation, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via Francesco Sforza No. 28, Milan 20122, Lombardy, Italy. evaldofavi@gmail.com
Key Words	Obinutuzumab; Rituximab; Kidney transplantation; Desensitization; Antibody-mediated rejection; Glomerulopathies; Recurrence; Review
Core Tip	Antibody-mediated rejection and recurrent primary renal diseases remain major causes of kidney transplant loss. Obinutuzumab (OBI) is a type 2 anti-CD20 monoclonal antibody with enhanced peripheral and central B-cell depletion capacities compared to type 1 anti-CD20 monoclonal antibodies. Compared to other B-cell-targeted agents, OBI-induced B-cell depletion is marginally affected by complement function, primarily operating through antibody-dependent cell cytotoxicity, antibody-dependent cell phagocytosis, and direct cell death. These characteristics suggest that OBI might represent a game-changer in the management of highly sensitized transplant candidates, humoral rejection, and relapsing renal diseases. This review summarizes the current knowledge on OBI use in kidney transplantation.
Citation	Favi E, Morabito M. Obinutuzumab in kidney transplantation: Past, present, and future. World J Transplant 2025; In press

Received	2025-04-27 05:39
Peer-Review Started	2025-04-27 05:39
To Make the First Decision
Return for Revision	2025-05-12 04:19
Revised	2025-05-26 08:02
Second Decision	2025-08-11 02:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-11 13:10
Articles in Press	2025-08-11 13:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
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